Conformational ensemble of the human TRPV3 ion channel

Abstract excerpt

<h4>Summary</h4> Transient receptor potential vanilloid channel 3 (TRPV3), a member of the thermosensitive TRP (thermoTRPV) channels, is activated by warm temperatures and serves as a key regulator of normal skin physiology through the release of pro-inflammatory messengers. Mutations in trpv3 have been identified as the cause of the congenital skin disorder, Olmsted syndrome. Unlike other members of the thermoT...

Topics

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• Cryoelectron Microscopy
• Ion Channel Gating
• Lipid Bilayers
• Models, Molecular
• Mutation
• Nanostructures
• Protein Conformation
• TRPV Cation Channels

Identifiers and source

Literature Corpus work

5c9ba47e-9bab-5e73-b441-ed914fe3206e

DOI

10.1101/395616