Article

Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci

2025-06-16

Abstract excerpt

Breast cancer drugs including anthracyclines (ACs) and Trastuzumab increase the risk for cardiovascular diseases (CVDs) such as atrial fibrillation (AF) and heart failure (HF) that ultimately affect the heart muscle. These CVDs are associated with hundreds of genetic variants in non- coding regions of the genome. However, how these drugs affect the regulatory potential of the non-coding genome of the heart and CVD...

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Literature Corpus work: 5c987c1f-24d2-59b3-8657-9ea0dc6515b0
DOI: 10.1101/2025.06.11.658997

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