Article

Single-cell genomics improves the discovery of risk variants and genes of Atrial Fibrillation

2022-02-05

Abstract excerpt

Genome-wide association studies (GWAS) have linked hundreds of loci to cardiac diseases. However, in most loci the causal variants and their target genes remain unknown. We developed a combined experimental and analytical approach that integrates single cell epigenomics with GWAS to prioritize risk variants and genes. We profiled accessible chromatin in single cells obtained from human hearts and leveraged the dat...

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Literature Corpus work: ce4306b3-5465-5833-9739-0fc48df073c4
DOI: 10.1101/2022.02.02.22270312

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