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Anthracyclines induce cardiotoxicity through a shared gene expression response signature

28 Feb 2024

Abstract excerpt

TOP2 inhibitors (TOP2i) are effective drugs for breast cancer treatment. However, they can cause cardiotoxicity in some women. The most widely used TOP2i include anthracyclines (AC) Doxorubicin (DOX), Daunorubicin (DNR), Epirubicin (EPI), and the anthraquinone Mitoxantrone (MTX). It is unclear whether women would experience the same adverse effects from all drugs in this class, or if specific drugs would be...

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PMID: 38416769
DOI: 10.1371/journal.pgen.1011164

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