Article

Conserved RNA–protein modules link early anthracycline responses to atrial fibrillation risk

2026-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Anthracycline chemotherapeutics increase risk for cardiovascular disease. The early molecular events that link inherited risk to cardiac dysfunction remain poorly defined. We therefore exposed iPSC-derived cardiomyocytes from six individuals to three anthracyclines and an anthracenedione, which act as topoisomerase inhibitors (TOP2i) to induce DNA damage, and generated proteomics data following...

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Literature Corpus work: 9f4a3bee-b0c1-5e8c-9496-01d2f5c8802d
DOI: 10.64898/2026.02.15.706019

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