Article

DNA damage-associated protein co-expression network in cardiomyocytes informs on tolerance to genetic variation and disease

2024-08-14

Abstract excerpt

<h4>Summary</h4> Cardiovascular disease (CVD) is associated with both genetic variants and environmental factors. One unifying consequence of the molecular risk factors in CVD is DNA damage, which must be repaired by DNA damage response proteins. However, the impact of DNA damage on global cardiomyocyte protein abundance, and its relationship to CVD risk remains unclear. We therefore treated induced pluripotent s...

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Literature Corpus work: 9ce3f3ba-36e7-5ad9-98d6-8788a97cc7e1
DOI: 10.1101/2024.08.14.607863

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