Article
Genome-Wide Association Study for Anthracycline-Induced Congestive Heart Failure.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2017
Schneider Bryan P, Shen Fei, Gardner Laura, Radovich Milan, Li Lang, Miller Kathy D, Jiang Guanglong, Lai Dongbing, O'Neill Anne, Sparano Joseph A, Davidson Nancy E, Cameron David, Gradus-Pizlo Irmina, Mastouri Ronald A, Suter Thomas M, Foroud Tatiana, Sledge George W
Abstract excerpt
PURPOSE: Anthracycline-induced congestive heart failure (CHF) is a rare but serious toxicity associated with this commonly employed anticancer therapy. The ability to predict which patients might be at increased risk prior to exposure would be valuable to optimally counsel risk-to-benefit ratio for each patient. Herein, we present a genome-wide approach for biomarker discovery with two validation cohorts to...
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