Article

Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice

2021-12-13

Abstract excerpt

<h4>SUMMARY</h4> Sickle cell disease (SCD) is an inherited blood disorder caused by a mutation in the HBB gene leading to hemoglobin S production and polymerization under hypoxia conditions leading to vaso-occlusion, chronic hemolysis, and progressive organ damage. This disease affects ∼100,000 people in the United States and millions worldwide. An effective therapy for SCD is fetal hemoglobin (HbF) induction by...

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Literature Corpus work: 5c67079e-851e-5e4e-a562-5c3bcc09d577
DOI: 10.1101/2021.12.13.472406

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