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Research in Sickle Cell Disease: From Bedside to Bench to Bedside

1 Jun 2021

Abstract excerpt

Sickle cell disease (SCD) is an exemplar of bidirectional translational research, starting with a remarkable astute observation of the abnormally shaped red blood cells that motivated decades of bench research that have now translated into new drugs and genetic therapies. Introduction of hydroxyurea (HU) therapy, the only SCD-modifying treatment for >30 years and now standard care, was initiated through another...

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PMID: 34095767
DOI: 10.1097/hs9.0000000000000584

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