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Article

Induction of fetal hemoglobin through enhanced translation efficiency of γ-globin mRNA

28 Aug 2014

Abstract excerpt

Fetal hemoglobin (HbF) induction can ameliorate the clinical severity of sickle cell disease and β-thalassemia. We previously reported that activation of the eukaryotic initiation factor 2α (eIF2α) stress pathway increased HbF through a posttranscriptional mechanism. In this study, we explored the underlying means by which salubrinal, an activator of eIF2α signaling, enhances HbF production in primary human...

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PMID: 25170120
DOI: 10.1182/blood-2014-03-564302

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