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Article

Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches

1 Nov 2016

Abstract excerpt

INTRODUCTION: Stress erythropoiesis induces fetal hemoglobin (HbF) expression in β-thalassemias, however the level of expression is highly variable. The last decade has seen dramatic advances in our understanding of the molecular regulators of HbF production and the genetic factors associated with HbF levels, leading to the promise of new methods of the clinical induction of HbF. Areas covered: This article will...

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Share to Hemoglobinopathies and Related Disorders
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PMID: 27801605
DOI: 10.1080/17474086.2016.1255142

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