Article

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

2023-01-23

Abstract excerpt

Although intestinal epithelial cells (IECs) can express major histocompatibility complex class II (MHC II), especially during intestinal inflammation, it remains unclear if antigen presentation by IECs favours pro- or anti-inflammatory CD4 + T cell responses. Using selective gene ablation of MHC II in IECs and IEC organoid cultures, we assessed the impact of MHC II expression by IECs on CD4 + T cell responses an...

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Literature Corpus work: 5c5baaa2-a92c-5441-9018-95b13503dfbe
DOI: 10.1101/2023.01.23.525150

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