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Article

Intraepithelial Lymphocytes of the Intestine

26 Jan 2024

Abstract excerpt

The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying tissue, harbors one of the largest lymphocyte populations in the body, intestinal intraepithelial lymphocytes (IELs). IELs must balance tolerance, resistance, and tissue protection to maintain epithelial homeostasis and barrier integrity. This review discusses the ontogeny, environmental imprinting, T cell receptor (TCR)...

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PMID: 38277691
DOI: 10.1146/annurev-immunol-090222-100246

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