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Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors.

Genome medicine - 16 Aug 2022

Wang Rui, Li Jingyun, Zhou Xin, Mao Yunuo, Wang Wendong, Gao Shuai, Wang Wei, Gao Yuan, Chen Kexuan, Yu Shuntai, Wu Xinglong, Wen Lu, Ge Hao, Fu Wei, Tang Fuchou

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related death worldwide with metastases being the main cause of cancer-related death. Here, we investigated the genomic and transcriptomic alterations in matching adjacent normal tissues, primary tumors, and metastatic tumors of CRC patients. METHODS: We performed whole genome sequencing (WGS), multi-region whole exome sequencing...

Topics

Colorectal Neoplasms
DNA Copy Number Variations
DNA, Complementary
Genomics
Humans
Mutation
Neoplasm Metastasis
Peroxisome Proliferator-Activated Receptors
Transcriptome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35974387
DOI: 10.1186/s13073-022-01093-z
PMCID: PMC9380328

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