Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear transcriptional condensates as drivers and therapeutic targets in NPM1-mutated AML.

Blood - 14 May 2026

Uckelmann Hannah J, Gadrey Jayant Y, Brunetti Lorenzo

Abstract excerpt

ABSTRACT: NPM 1-mutated acute myeloid leukemia (AML) is driven by aberrant HOX/MEIS1 expression, whose mechanistic basis remained unresolved for years. Recent paradigm-shifting studies show that mutant NPM1 organizes phase-separated nuclear condensates that concentrate transcriptional regulators at active chromatin, directly sustaining the pathogenic HOX/MEIS1 transcriptional program. This framework explains the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Gene Expression Regulation, Leukemic
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Proto-Oncogene Proteins

Share to Transcription, Genetic

Source

Identifiers

PMID: 41949617
DOI: 10.1182/blood.2025031880

Genes

MEIS1
NPM1
KMT2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear transcriptional condensates as drivers and therapeutic targets in NPM1-mutated AML.PMID 41949617Read ↗

Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid LeukemiaSemantic proximity Read ↗

Disparate leukemia mutations converge on nuclear phase-separated condensates.Semantic proximity Read ↗

Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid LeukemiaSemantic proximity Read ↗

Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid LeukemiaSemantic proximity Read ↗

A Unified Model: Chromatin-Bound Multicomponent Condensates.Semantic proximity Read ↗

Targeting chromatin modifying complexes in acute myeloid leukemiaSemantic proximity Read ↗

Therapeutic targeting in pediatric acute myeloid leukemia with aberrant HOX/MEIS1 expressionSemantic proximity Read ↗

Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation.Semantic proximity Read ↗

Combined Menin and XPO1 inhibition drive synergistic antileukemic activity in <i>KMT2A</i> r and <i>NPM1</i> -m AMLSemantic proximity Read ↗

Regulation of HOX gene expression in AMLSemantic proximity Read ↗

MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i> -Rearranged Acute Myeloid LeukemiaSemantic proximity Read ↗

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.