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Cell-Free DNA Methylation of Selected Genes Allows for Early Detection of the Major Cancers in Women

26 Sept 2018

Abstract excerpt

Background: Breast (BrC), colorectal (CRC) and lung (LC) cancers are the three most common and deadly cancers in women. Cancer screening entails an increase in early stage disease detection but is hampered by high false-positive rates and overdiagnosis/overtreatment. Aberrant DNA methylation occurs early in cancer and may be detected in circulating cell-free DNA (ccfDNA), constituting a valuable biomarker and...

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PMID: 30261643
DOI: 10.3390/cancers10100357

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