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Complex Landscape of Germline Variants in Brazilian Patients With Hereditary and Early Onset Breast Cancer

7 May 2018

Abstract excerpt

Pathogenic variants in known breast cancer (BC) predisposing genes explain only about 30% of Hereditary Breast Cancer (HBC) cases, whereas the underlying genetic factors for most families remain unknown. Here, we used whole-exome sequencing (WES) to identify genetic variants associated to HBC in 17 patients of Brazil with familial BC and negative for causal variants in major BC risk genes (BRCA1/2, TP53 and CHEK2...

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PMID: 29868112
DOI: 10.3389/fgene.2018.00161

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