Article
Placental Epigenome-Wide Association Study Identified Loci Associated with Childhood Adiposity at 3 Years of Age.
International journal of molecular sciences - 29 Sept 2020
Gagné-Ouellet Valérie, Breton Edith, Thibeault Kathrine, Fortin Carol-Ann, Desgagné Véronique, Girard Tremblay Élise, Cardenas Andres, Guérin Renée, Perron Patrice, Hivert Marie-France, Bouchard Luigi
Abstract excerpt
The aim of this study was to identify placental DNA methylation (DNAm) variations associated with adiposity at 3 years of age. We quantified placental DNAm using the Infinium MethylationEPIC BeadChips. We assessed associations between DNAm at single-CpGs and skinfold thickness using robust linear regression models adjusted for gestational age, child's sex, age at follow-up and cellular heterogeneity. We sought...
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