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Article

Placental genomics mediates genetic associations with complex health traits and disease.

Nature communications - 4 Feb 2022

Bhattacharya Arjun, Freedman Anastasia N, Avula Vennela, Harris Rebeca, Liu Weifang, Pan Calvin, Lusis Aldons J, Joseph Robert M, Smeester Lisa, Hartwell Hadley J, Kuban Karl C K, Marsit Carmen J, Li Yun, O'Shea T Michael, Fry Rebecca C, Santos Hudson P

Abstract excerpt

As the master regulator in utero, the placenta is core to the Developmental Origins of Health and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene-trait associations (GTAs) across the life course, we perform distal mediator-enriched transcriptome-wide association studies (TWAS) for 40 traits, integrating placental multi-omics from the Extremely Low Gestational Age Newborn...

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Identifiers

PMID: 35121757
DOI: 10.1038/s41467-022-28365-x
PMCID: PMC8817049

Genes

EPS15
SPATA13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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