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Article

Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages.

Journal of translational medicine - 22 May 2023

Lu Yuheng, Zhang Hongbo, Pan Haoyan, Zhang Zhicheng, Zeng Hua, Xie Haoyu, Yin Jianbin, Tang Wen, Lin Rengui, Zeng Chun, Cai Daozhang

Abstract excerpt

BACKGROUND: Disruption of N6 methyl adenosine (m6A) modulation hampers gene expression and cellular functions, leading to various illnesses. However, the role of m6A modification in osteoarthritis (OA) synovitis remains unclear. This study aimed to explore the expression patterns of m6A regulators in OA synovial cell clusters and identify key m6A regulators that mediate synovial macrophage phenotypes. METHODS:...

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Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Inflammation
Macrophages
Osteoarthritis
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Synovial Membrane

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PMID: 37217897
DOI: 10.1186/s12967-023-04173-9
PMCID: PMC10204300

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