Article

HLA-DQ2/8 genotype is associated with strain-level gut microbiome divergence and lower serum pantothenate in healthy adults

2025-10-20

Abstract excerpt

HLA-DQ2/8 haplotypes are established genetic risk factors for autoimmune diseases and are known to influence gut microbiota assembly in early life. However, their impact on the adult microbiome and functional consequences for host physiology remain unclear. Here, we performed a genotype-stratified multi-omics analysis of 60 healthy adults, including 28 HLA-DQ2/8 carriers and 32 non-carriers. We found that host HLA...

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Literature Corpus work: 5c10362e-10d9-5947-875d-b28c70f2aaec
DOI: 10.1101/2025.10.20.683361

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HLA-DQ2/8 genotype is associated with strain-level gut microbiome divergence and lower serum pantothenate in healthy adultsDOI 10.1101/2025.10.20.683361Read

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