Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome.

doi:10.1038/s41467-019-11460-x

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Article

Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome.

Nature communications - 9 Aug 2019

Russell Jordan T, Roesch Luiz F W, Ördberg Malin, Ilonen Jorma, Atkinson Mark A, Schatz Desmond A, Triplett Eric W, Ludvigsson Johnny

Abstract excerpt

Susceptibility to many human autoimmune diseases is under strong genetic control by class II human leukocyte antigen (HLA) allele combinations. These genes remain by far the greatest risk factors in the development of type 1 diabetes and celiac disease. Despite this, little is known about HLA influences on the composition of the human gut microbiome, a potential source of environmental influence on disease. Here,...

Topics

Alleles
Autoimmune Diseases
Autoimmunity
Bacteria
Biodiversity
Celiac Disease
Child
Child, Preschool
Diabetes Mellitus, Type 1
Feces
Gastrointestinal Microbiome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Haplotypes

Histocompatibility Antigens Class II

Humans

Infant

RNA, Ribosomal, 16S

Source

Open in PubMed Open full text

Identifiers

PMID: 31399563
DOI: 10.1038/s41467-019-11460-x
PMCID: PMC6689114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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