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Article

The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition.

Nature genetics - 1 Mar 2026

Moksnes Marta Riise, Coward Eivind, Nethander Maria, Dekkers Koen, Grahnemo Louise, Törnqvist Anna E, Li Lei, Lundmark Per, Pertiwi Kamalita, Baldanzi Gabriel, Mjelle Robin, Moll Janne Marie, Eklund Aron Charles, Nielsen Henrik Bjørn, Svensson Johan, Langhammer Arnulf, Giskeødegård Guro F, Brumpton Ben, Hjort Rebecka, Ness-Jensen Eivind, Engström Gunnar, Pelaseyed Thaher, Michaëlsson Karl, Orho-Melander Marju, Fall Tove, Hveem Kristian, Ohlsson Claes

Abstract excerpt

The gut microbiota is associated with human health and disease. Here we conducted a genome-wide association study of host genetic factors influencing gut microbiota composition in 12,652 individuals from the Trøndelag Health Study (HUNT), with replication in Nordic cohorts (n = 16,017-21,976). We identified 12 reproducible SNP-species associations across six genomic loci, including known (LCT, ABO) and novel...

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Source

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Identifiers

PMID: 41688637
DOI: 10.1038/s41588-026-02502-4
PMCID: PMC12987729

Genes

ABO
FUT2
LCT
MUC12
SLC37A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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