Article

Macrophages induce stromal differentiation and endothelialization in iPSC-derived kidney organoids

2025-11-13

Abstract excerpt

Human induced pluripotent stem cell (iPSC) - derived kidney organoids are powerful models of kidney development and disease but lack mature vasculature. Here, we show that co-culture with human monocyte-derived macrophages (MDM) induces robust endothelial and stromal differentiation in iPSC-derived kidney organoids. MDM promoted the formation of lumenized capillary networks, an effect reproduced by iPSC-derived ma...

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Literature Corpus work: 27bb8d36-9bca-51fc-82f3-571cfdea120b
DOI: 10.1101/2025.11.13.688016

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