Article
Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization and de novo cell types
2023-05-30
Abstract excerpt
Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, organ mimicry, and ultimately transplantation in a clinical setting thereby hinges on achieving robust vascularization of in vitro engineered organs. Here, focusing on human kidney organoids, we overcome this hurdle by combining an inducible ETS translocation variant 2 ( ETV2 ) human induced pluripotent stem cel...
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Identifiers and source
- Literature Corpus work
- 2edf1ab4-6154-5726-8914-fdf946de0d8f
- DOI
- 10.1101/2023.05.30.542848