Article

The FSGS disease gene product and nuclear pore protein NUP205 regulates nuclear localization and activity of the transcriptional regulators YAP and TAZ in podocytes

2023-03-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mutations in genes encoding nuclear pore proteins (NUPs) cause steroid-resistant nephrotic syndrome (SRNS) and focal and segmental glomerulosclerosis (FSGS). The mechanisms of how NUP deficiency may cause podocyte dysfunction and failure of the kidney filtration barrier are elusive. The tightly controlled activity of the transcriptional effectors of the evolutionarily conser...

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Literature Corpus work: 6352d626-ad4c-59ca-883a-8ead1553993a
DOI: 10.1101/2023.03.07.531564

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