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The Pharmaceutical Potential of Histone Deacetylase Inhibitors

28 Aug 2007

Abstract excerpt

Protein acetylation, catalyzed by the opposing activities of histone deacetylases (HDAC) and histone acetyltransferases, is now recognized to be an important epigenetic modulator of gene transcriptional activity and cell function. As a result of the intense search for HDAC inhibitors (HDACi) during the past fifteen years, a large number of structurally divergent classes with variable potencies and isoenzyme...

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PMID: 17897003
DOI: 10.2174/138161207781663064

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