Article
Assembly and substrate recognition of curli biogenesis system.
Nature communications - 13 Jan 2020
Yan Zhaofeng, Yin Meng, Chen Jianan, Li Xueming
Abstract excerpt
A major component of bacterial biofilms is curli amyloid fibrils secreted by the curli biogenesis system. Understanding the curli biogenesis mechanism is critical for developing therapeutic agents for biofilm-related infections. Here we report a systematic study of the curli biogenesis system, highlighted by structural, biochemical and functional analysis of the secretion channel complexes (CsgF-CsgG) with and...
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