Article

Structural Tuning of HEWL Amyloid Polymorphs Enhances Antibacterial Activity Against Gram-Positive and Gram-Negative Pathogens

2026-07-14

Abstract excerpt

Amyloid fibrils are traditionally associated with protein misfolding disorders; however, increasing evidence indicates that they can also perform beneficial biological functions, including antimicrobial defense. Here, we investigated whether structurally distinct amyloid polymorphs of hen egg white lysozyme (HEWL) exhibit enhanced antibacterial activity compared with the native protein. HEWL was converted into two...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6d863a3-cec0-5665-8e7b-86982a4cb256
DOI: 10.64898/2026.07.13.738270

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural Tuning of HEWL Amyloid Polymorphs Enhances Antibacterial Activity Against Gram-Positive and Gram-Negative PathogensDOI 10.64898/2026.07.13.738270Read

Bacterial amyloids.Semantic proximity Read

Functional amyloids in bacteria.Semantic proximity Read

Emerging Roles of Functional Bacterial Amyloids in Gene Regulation, Toxicity, and ImmunomodulationSemantic proximity Read

Modulating Innate Immune Responses to Curli Fibers Through Protein EngineeringSemantic proximity Read

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway OligomersSemantic proximity Read

The Role of Functional Amyloids in Bacterial VirulenceSemantic proximity Read

Polymerizing the fibre between bacteria and host cells: the biogenesis of functional amyloid fibresSemantic proximity Read

Structural Mimicry in Microbial and Antimicrobial AmyloidsSemantic proximity Read

Exploiting amyloid: how and why bacteria use cross-β fibrilsSemantic proximity Read

Biophysical and structural characterisation of functional bacterial amyloid secretion systemsSemantic proximity Read

The Evolution of Functional Amyloids and Their Impact on Host–Microbe InteractionsSemantic proximity Read

Predicted Loop Regions Promote Aggregation: A Study of Amyloidogenic Domains in the Functional Amyloid FapC.Semantic proximity Read