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Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive Autoimmunity

11 May 2022

Abstract excerpt

The bacterial amyloid curli, produced by Enterobacteriales including Salmonella species and Escherichia coli , is implicated in the pathogenesis of several complex autoimmune diseases. Curli binds to extracellular DNA, and these complexes drive autoimmunity via production of anti-double-stranded DNA autoantibodies. Here, we investigated immune activation by phenol-soluble modulins (PSMs), the amyloid proteins...

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PMID: 35646719
DOI: 10.3389/fcimb.2022.884065

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