Article

Molecular determinants of Karyopherin-β2 chaperone and disaggregation activity

2022-09-15

Abstract excerpt

Karyopherin-β2 (Kapβ2) is a nuclear-import receptor that recognizes proline-tyrosine nuclear localization signals (PY-NLSs) of diverse cytoplasmic cargo for transport to the nucleus. Kapβ2 cargo include several disease-linked RNA-binding proteins (RBPs) with prion-like domains (PrLDs), such as FUS, TAF15, EWSR1, hnRNPA1, and hnRNPA2. These RBPs with PrLDs are linked via pathology and genetics to debilitating degen...

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Literature Corpus work: 6ff8c15d-97b7-5f15-be34-dd1f3bfd7afc
DOI: 10.1101/2022.09.14.508025

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