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Article

Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesis

21 Jan 2024

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurological disorders that share neurodegenerative pathways and features. The most prevalent genetic causes of ALS/FTD is the GGGGCC hexanucleotide repeat expansions in the first intron region of the chromosome 9 open reading frame 72 (C9orf72) gene. In this review, we comprehensively summarize the accumulating evidences...

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PMID: 38318532
DOI: 10.3389/fnmol.2024.1322720

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