Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.

doi:10.1016/j.cell.2018.03.002

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Article

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.

Cell - 19 Apr 2018

Guo Lin, Kim Hong Joo, Wang Hejia, Monaghan John, Freyermuth Fernande, Sung Julie C, O'Donovan Kevin, Fare Charlotte M, Diaz Zamia, Singh Nikita, Zhang Zi Chao, Coughlin Maura, Sweeny Elizabeth A, DeSantis Morgan E, Jackrel Meredith E, Rodell Christopher B, Burdick Jason A, King Oliver D, Gitler Aaron D, Lagier-Tourenne Clotilde, Pandey Udai Bhan, Chook Yuh Min, Taylor J Paul, Shorter James

Abstract excerpt

RNA-binding proteins (RBPs) with prion-like domains (PrLDs) phase transition to functional liquids, which can mature into aberrant hydrogels composed of pathological fibrils that underpin fatal neurodegenerative disorders. Several nuclear RBPs with PrLDs, including TDP-43, FUS, hnRNPA1, and hnRNPA2, mislocalize to cytoplasmic inclusions in neurodegenerative disorders, and mutations in their PrLDs can accelerate...

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Identifiers

PMID: 29677512
DOI: 10.1016/j.cell.2018.03.002
PMCID: PMC5911940

Genes

FUS
EWSR1
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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