Article

JNK1 And Downstream Signalling Hubs Regulate Anxiety-Like Behaviours In A Zebrafish Larvae Phenotypic Screen

2024-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Current treatments for anxiety and depression show limited efficacy in many patients indicating that research into new underlying mechanisms is needed. Inhibition of JNK1 has been shown to evoke an anxiolytic-and antidepressant-like phenotype in mice however the downstream effectors that elicit these behavioural effects are unknown. Here we employ a zebrafish ( D. Rerio ) larvae behavioural ass...

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Literature Corpus work: 5bba0b06-ce54-559f-81d3-e3719a40c333
DOI: 10.1101/2024.01.09.574843

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