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Article

Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen.

Scientific reports - 15 May 2024

Hong Ye, Sourander Christel, Hackl Benjamin, Patton Jedidiah S, John Jismi, Paatero Ilkka, Coffey Eleanor

Abstract excerpt

Current treatments for anxiety and depression show limited efficacy in many patients, indicating the need for further research into the underlying mechanisms. JNK1 has been shown to regulate anxiety- and depressive-like behaviours in mice, however the effectors downstream of JNK1 are not known. Here we compare the phosphoproteomes from wild-type and Jnk1-/- mouse brains and identify JNK1-regulated signalling...

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Identifiers

PMID: 38750129
DOI: 10.1038/s41598-024-61337-3
PMCID: PMC11096340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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