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Article

Proteome profile of telencephalon associates attenuated neurogenesis with chronic stress induced mood disorder phenotypes in zebrafish model.

Pharmacology, biochemistry, and behavior - 1 May 2021

Reddy Bommana Raghunath, Babu Nukala Sarath, Das Tapatee, Bhattacharya Dwaipayan, Murthy Ch Lakshmi N, Kumar Arvind, Idris Mohammed M, Chakravarty Sumana

Abstract excerpt

Debilitating mental illness like depression and related mood disorders is due to the disruption in circuitry that controls emotion, motivation, and reward, characterized by disparate phenotypes like decrease in socialization, motivation, threshold for threat apprehension, etc. Chronic stress is a major factor in the etiology of these disorders. Here, using a chronic unpredictable stress (CUS) paradigm the...

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PMID: 33684455
DOI: 10.1016/j.pbb.2021.173170

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