Article

Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

2023-11-29

Abstract excerpt

By exposing genes associated with disease, genomic studies provide hundreds of starting points that should lead to druggable processes. However, our ability to systematically translate these genomic findings into biological pathways remains limited. Here, we combine rapid loss-of-function mutagenesis of Alzheimer’s risk genes and behavioural pharmacology in zebrafish to predict disrupted processes and candidate th...

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Literature Corpus work: d36d8ae6-9c5a-5a0d-9587-5ca549a436e9
DOI: 10.1101/2023.11.28.568940

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