Article

Finding Drug Repurposing Candidates for Neurodegenerative Diseases using Zebrafish Behavioral Profiles

2023-09-13

Abstract excerpt

Drug repurposing can accelerate drug development while reducing the cost and risk of toxicity typically associated with de novo drug design. Several disorders lacking pharmacological solutions and exhibiting poor results in clinical trials - such as Alzheimer’s disease (AD) - could benefit from a cost-effective approach to finding new therapeutics. We previously developed a neural network model, Z-LaP Tracker, cap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fd49103-d47a-5f1c-96a9-ad5f955070c7
DOI: 10.1101/2023.09.12.557235

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Finding Drug Repurposing Candidates for Neurodegenerative Diseases using Zebrafish Behavioral ProfilesDOI 10.1101/2023.09.12.557235Read

High-throughput analysis of behavior for drug discovery.Semantic proximity Read

Zebrafish Larvae Behavior Models as a Tool for Drug Screenings and Pre-Clinical Trials: A Review.Semantic proximity Read

A KNIME-Based Analysis of the Zebrafish Photomotor Response Clusters the Phenotypes of 14 Classes of Neuroactive Molecules.Semantic proximity Read

Using the zebrafish photomotor response for psychotropic drug screening.Semantic proximity Read

Zebrafish behavioral phenotyping: Current assays, automated platforms, and the emerging need for AI in neuroscience, drug discovery and toxicology.Semantic proximity Read

Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genesSemantic proximity Read

Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planariansSemantic proximity Read

Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish.Semantic proximity Read

Long-Term Benefits of TUDCA Supplement in ARSACS Zebrafish ModelSemantic proximity Read

SAMBA: A Segment Anything Model-based tool for semi-automated Behavioural Analysis of <i>Drosophila</i> and other model organismsSemantic proximity Read

Multibehavioral Phenotyping in Early-Life-Stage Zebrafish for Identifying Disruptors of Nonassociative Learning.Semantic proximity Read

Virtual Screening and Zebrafish Phenotype-Based Evaluation Argues Against Repurposing 4-Phenylbutyrate for STXBP1-Related Disorders.Semantic proximity Read