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Article

A KNIME-Based Analysis of the Zebrafish Photomotor Response Clusters the Phenotypes of 14 Classes of Neuroactive Molecules.

Journal of biomolecular screening - 1 Jun 2016

Copmans Daniëlle, Meinl Thorsten, Dietz Christian, van Leeuwen Matthijs, Ortmann Julia, Berthold Michael R, de Witte Peter A M

Abstract excerpt

Recently, the photomotor response (PMR) of zebrafish embryos was reported as a robust behavior that is useful for high-throughput neuroactive drug discovery and mechanism prediction. Given the complexity of the PMR, there is a need for rapid and easy analysis of the behavioral data. In this study, we developed an automated analysis workflow using the KNIME Analytics Platform and made it freely accessible. This...

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PMID: 26637551
DOI: 10.1177/1087057115618348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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