Article

HDAC11-Driven STAT3 Activation Modulates Epigenetic Regulation, Promoting Pro-Inflammatory Cytokine Production and Endothelial Dysfunction in Diabetes

2025-07-21

Abstract excerpt

<title>Abstract</title> <p>Diabetes mellitus is marked by chronic low-grade inflammation, increasing the risk of infections and vascular complications. In this study, we uncover a novel link between bacterial infection and epigenetic regulation in diabetes. We found that infection with Escherichia coli strongly induces the expression of histone deacetylase 11 (HDAC11) in endothelial cell-derived induced pluripot...

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Literature Corpus work: 5bb284b8-e0ad-5bf5-b60a-9229d0241d26
DOI: 10.21203/rs.3.rs-6837535/v1

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