Histone deacetylases and their inhibitors: molecular mechanisms and therapeutic implications in diabetes mellitus

Abstract excerpt

Epigenetic mechanisms such as DNA methylation, histone modification and microRNA changes have been shown to be important for the regulation of cellular functions. Among them, histone deacetylases (HDACs) are enzymes that balance the acetylation activities of histone acetyltransferases in chromatin remodeling and play essential roles in gene transcription to regulate cell proliferation, migration and death. Recent...

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• Autophagy in Disease and Therapy
• Histone Deacetylase Inhibitors Research
• Sirtuins and Resveratrol in Medicine

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Literature Corpus work

3c1f951c-af84-58ca-b959-a73fe32d87da

DOI

10.1016/j.apsb.2012.06.005