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Article

HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3

2 Sept 2022

Abstract excerpt

Fungal infections cause serious health problems, especially in patients with an immune-deficiency. Histone deacetylase 11 (HDAC11) mediates various immune functions, yet little is known about its role in regulating host immune responses to fungal infection. Here we report that HDAC11 negatively controls antifungal immunity in macrophages and dendritic cells. Deleting Hdac11 protects mice from morbidity and...

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Identifiers

PMID: 36087429
DOI: 10.1016/j.redox.2022.102461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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