Article

Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury

2022-04-14

Abstract excerpt

Although protein synthesis is hypothesized to have a pivotal role in axonal repair after central nervous system (CNS) injury, the role of core components of the protein synthesis machinery has not been examined. Notably, some elongation factors possess non-canonical functions that may further impact axonal repair. Here, we examined whether overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins enhanc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 49bfed85-2f67-5a3c-8d31-b938dc196fd6
DOI: 10.1101/2022.04.14.488293

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injuryDOI 10.1101/2022.04.14.488293Read

Inositol Polyphosphate-5-phosphatase K ( <i>Inpp5k</i> ) enhances sprouting of corticospinal tract axons after CNS traumaSemantic proximity Read

Corticospinal neurons respond differentially to neurotrophins and myelin-associated glycoprotein in vitro.Semantic proximity Read

Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injurySemantic proximity Read

Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates.Semantic proximity Read

KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neuronsSemantic proximity Read

Hyperactivated Stat3 boosts axon regeneration in the CNS.Semantic proximity Read

KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neuronsSemantic proximity Read

The role of TSC1 and TSC2 proteins in neuronal axons.Semantic proximity Read

Replating induces mTOR-dependent rescue of protein synthesis in Charcot-Marie-Tooth diseased neuronsSemantic proximity Read

Autism- and epilepsy-associated EEF1A2 mutations lead to translational dysfunction and altered actin bundling.Semantic proximity Read

Axonal mRNA transport and translation at a glanceSemantic proximity Read

C-terminal domain small phosphatase 1 (CTDSP1) regulates growth factor expression and axonal regenerationSemantic proximity Read