Article
Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates.
PloS one - 1 Jan 2012
Buchser William J, Smith Robin P, Pardinas Jose R, Haddox Candace L, Hutson Thomas, Moon Lawrence, Hoffman Stanley R, Bixby John L, Lemmon Vance P
Abstract excerpt
Trauma to the spinal cord and brain can result in irreparable loss of function. This failure of recovery is in part due to inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans (CSPGs). Peripheral nervous system (PNS) neurons exhibit increased regenerative ability compared to central nervous system neurons, even in the presence of inhibitory environments. Previously, we identified over a...
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