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Single-cell and spatially resolved analysis uncovers cell heterogeneity of breast cancer

3 Mar 2022

Abstract excerpt

The heterogeneity and the complex cellular architecture have a crucial effect on breast cancer progression and response to treatment. However, deciphering the neoplastic subtypes and their spatial organization is still challenging. Here, we combine single-nucleus RNA sequencing (snRNA-seq) with a microarray-based spatial transcriptomics (ST) to identify cell populations and their spatial distribution in breast...

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PMID: 35241110
DOI: 10.1186/s13045-022-01236-0

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