Article

NELL-1 regulates the matrisome to alter osteosarcoma disease progression

2022-01-23

Abstract excerpt

Sarcomas produce abnormal extracellular matrix (ECM) which in turn provides instructive cues for cell growth and invasion. Neural EGF Like-Like molecule 1 (NELL1) is a secreted glycoprotein characterized by its non-neoplastic osteoinductive effects, yet highly expressed in skeletal sarcomas. Here, NELL1 gene deletion markedly reduced invasive behavior across human osteosarcoma (OS) cell lines. This resulted in re...

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Literature Corpus work: 5b4b880a-c6ce-54ac-9ff0-b92edba9cb8e
DOI: 10.1101/2022.01.21.477245

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