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The Extracellular Matrix in Soft Tissue Sarcomas: Pathobiology and Cellular Signalling

9 Dec 2021

Abstract excerpt

Soft tissue sarcomas are rare cancers of mesenchymal origin or differentiation comprising over 70 different histological subtypes. Due to their mesenchymal differentiation, sarcomas are thought to produce and deposit large quantities of extracellular matrix (ECM) components. Interactions between ECM ligands and their corresponding adhesion receptors such as the integrins and the discoidin domain receptors play...

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PMID: 34957097
DOI: 10.3389/fcell.2021.763640

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