Article

VCAN is essential for ERK5-driven tumorigenesis in soft tissue sarcoma

2025-05-28

Abstract excerpt

<h4>ABSTRACT</h4> The ERK5 signaling pathway has recently emerged as a critical regulator of soft tissue sarcoma (STS) biology, contributing to tumor initiation, progression, and maintenance. In this study, we identify VCAN, a chondroitin sulfate proteoglycan, as a novel transcriptional target of ERK5 and a central mediator of ERK5-related oncogenesis. Through a combination of genetic (silencing, overexpression)...

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Literature Corpus work: 060c1c6f-f859-5270-99b3-adfcd4f4195b
DOI: 10.1101/2025.05.28.654281

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