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Disease Tolerance Acquired Through Repeated <i>Plasmodium</i> Infection Involves Epigenetic Reprogramming of Innate Immune Cells

2023-04-21

Abstract excerpt

<h4>Summary</h4> The regulation of inflammation is a critical aspect of disease tolerance and naturally acquired immunity to malaria. Here, we demonstrate using RNA sequencing and epigenetic landscape profiling by cytometry by Time-Of-Flight (EpiTOF), that the regulation of inflammatory pathways during asymptomatic parasitemia occurs downstream of pathogen sensing—at the epigenetic level. The abundance of certain...

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Literature Corpus work
5b3bd3d0-d6ba-563a-acaf-642bedc7b5b1
DOI
10.1101/2023.04.19.537546
Open publication

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Disease Tolerance Acquired Through Repeated <i>Plasmodium</i> Infection Involves Epigenetic Reprogramming of Innate Immune CellsDOI 10.1101/2023.04.19.537546
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