Article

<i>Leishmania</i> targets the macrophage epigenome and dampens the NF-κB/NLRP3-mediated inflammatory response

2019-05-24

Abstract excerpt

<h4>Summary</h4> Aberrant macrophage activation during intracellular infection generates important immunopathologies that can cause severe human morbidity. A better understanding of microbial immune subversion strategies and macrophage phenotypic and functional responses is a prerequisite for the design of novel, host-directed intervention strategies. Here, we uncover a fine-tuned transcriptional response induced...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69de68bf-48d4-51fc-86fd-26fe673eb293
DOI: 10.1101/649632

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Leishmania</i> targets the macrophage epigenome and dampens the NF-κB/NLRP3-mediated inflammatory responseDOI 10.1101/649632Read

Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory ResponseSemantic proximity Read

Single-cell ATAC sequencing identifies sleepy macrophages during reciprocity of cytokines in L. major infectionSemantic proximity Read

<i>Leishmania amazonensis</i> controls macrophage-regulated cell death to establish chronic infection <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

Dual Transcriptome Profiling of<i>Leishmania</i>-Infected Human Macrophages Reveals Distinct Reprogramming SignaturesSemantic proximity Read

Leishmania donovani Subverts Host Immune Response by Epigenetic Reprogramming of Macrophage M(Lipopolysaccharides + IFN-γ)/M(IL-10) PolarizationSemantic proximity Read

Leishmania-Host Interactions—An Epigenetic ParadigmSemantic proximity Read

Disease Tolerance Acquired Through Repeated <i>Plasmodium</i> Infection Involves Epigenetic Reprogramming of Innate Immune CellsSemantic proximity Read

MAPPING CHANGES OF MIRNA-MRNA NETWORKS IN <i>LEISHMANIA-INFECTED</i> MACROPHAGES PREDICTS REGULATORY MIRNA-TF LOOPS AS NOVEL TARGETS OF PARASITE IMMUNE SUBVERSIONSemantic proximity Read

Direct RNA sequencing reveals selective remodeling of the host m6A epitranscriptome during Leishmania infectionSemantic proximity Read

Epigenetic landscape of the H3K27me3 mark in macrophages transformed by <i>Theileria annulata</i>Semantic proximity Read

Temporal Expression Dynamics of lncRNAs and Cis-Target Gene Interactions in Leishmania major-Infected Human MacrophagesSemantic proximity Read

In vivo reprogramming of murine host immune response genes following Leishmania major infectionSemantic proximity Read